The molecular architecture of the inner ear
نویسندگان
چکیده
منابع مشابه
The molecular architecture of the inner ear.
The inner ear is structurally complex. A molecular description of its architecture is now emerging from the use of contemporary methods of cell and molecular biology, and from studies of ontogenetic development. With the application of clinical and molecular genetics, it has now become possible to identify genes associated with inherited, non-syndromic deafness and balance dysfunction in humans...
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Mutations of SLC26A4 are a common cause of hearing loss associated with enlargement of the endolymphatic sac (EES). Slc26a4 expression in the developing mouse endolymphatic sac is required for acquisition of normal inner ear structure and function. Here, we show that the mouse endolymphatic sac absorbs fluid in an SLC26A4-dependent fashion. Fluid absorption was sensitive to ouabain and gadolini...
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Molecular mechanisms of inner ear development.
The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Henc...
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ژورنال
عنوان ژورنال: British Medical Bulletin
سال: 2002
ISSN: 1471-8391,0007-1420
DOI: 10.1093/bmb/63.1.5